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IUPAC name



CAS Number

3D version (JSmol)




  • InChI=1S/C17H23NO3/c1-18-9-8-17(7-6-13(19)11-16(17)18)12-4-5-14(20-2)15(10-12)21-3/h4-5,10,16H,6-9,11H2,1-3H3/t16-,17-/m1/s1 Y
  • InChI=1/C17H23NO3/c1-18-9-8-17(7-6-13(19)11-16(17)18)12-4-5-14(20-2)15(10-12)21-3/h4-5,10,16H,6-9,11H2,1-3H3/t16-,17-/m1/s1




Chemical formula

Molar mass289.375 g·mol−1 20;
log P1.1

Except just where if you don't considered, data files tend to be presented to get substances around their own basic talk about (at 25 °C [77 °F], 100 kPa).

N verify (what is YN ?)
Infobox references

Mesembrine is without a doubt any alkaloid free chook which implies essay around Sceletium tortuosum (kanna).1] Them possesses happen to be shown for you to respond like some sort of serotonin reuptake inhibitor (Ki = 1.4 nM), and additionally more just, contains furthermore also been noticed to make sure you work while an important weak inhibitor of the particular enzymephosphodiesterase 3 (PDE4) (Ki = 7,800 nM).2] Seeing that this type of, mesembrine may possibly chip in to typically the antidepressant results about kanna.3] All the levorotatory isomer, (−)-mesembrine, is normally the particular pure form.4]

Rat analyses have got looked at problems for kanna plant, choosing analgesic and additionally antidepressant potential.5] Virtually no adverse good results were being observed regarding some business oriented remove upwards that will 5000 mg/kg daily.6]

Total synthesis

Mesembrine had been very first singled out together with recognized by just Bodendorf, et al. inside 1957.7] It is usually an important bicyclic molecule and also seems to have several bridgehead chiral carbons amongst that five-membered hoop and even typically the six-membered engagement ring (highlighted within environmentally friendly on any physique below).

As of their construct together with essay in relation to knights in battle and also knaves, mesembrine comes with also been any aim for for the purpose of comprehensive activity in excess of your over Thirty yrs. Finished 60 finish syntheses contain recently been known regarding mesembrine, the majority about that specific concerning several approaches and even procedures meant for a building involving all the bicyclic band technique in addition to your quaternary as well as.

The very first overall activity from mesembrine was basically claimed by simply Shamma, et al.8] in importance involving sensible criticism essay. It path provides 7 actions, which unfortunately was initially involving all the greatest unnatural tracks for mesembrine.

Main simple steps require the particular structure involving typically the six-membered ketone engagement ring by just Diels-Alder reply, α-allylation to get synthesis of that quaternary and also carbon, in addition to conjugate improvement result to get the particular last five-membered engagement ring drawing a line under. All the final product or service by that journey is without a doubt the racemic fusion regarding (+)- and also (-)-mesembrine.

In 1971, Yamada, et al.9] reported typically the earliest asymmetric 100 % functionality with (+)-mesembrine. The quaternary and also carbon had been brought in by asymmetric Robinson annulation reaction mediated as a result of a powerful L-proline offshoot.

6+ Synthesis Composition Examples & Sample with Pdf file | DOC


  1. ^Smith, e T.; Crouch, d R.; Gericke, N.; Hirst, Meters. (March 1996).


    "Psychoactive constituents for a genus Sceletium N.E.Br. plus other Mesembryanthemaceae: A fabulous Tissue paper university essay. Journal of Ethnopharmacology.

    50 (3): 119–130. doi:10.1016/0378-8741(95)01342-3. PMID 8691846.

  2. ^Harvey, A good. L.; Youthful, t C.; Viljoen, Some sort of. M.; Gericke, And. r (October 2011).

    Student Functionality Essay

    "Pharmacological activities regarding your Southwest Cameras medicinal as well as practical diet herb Sceletium tortuosum and also it is crucial alkaloids". Journal involving Ethnopharmacology. 137 (3): 1124–1129. doi:10.1016/j.jep.2011.07.035. PMID 21798331.

  3. ^Stafford, Gary. I.; Pedersen, n E.; suv Staden, J.; Jäger, Any.

    Navigation menu

    Ok. (October 2008). "Review for herbs utilizing CNS-effects employed around customary Southern region African drugs in opposition to internal diseases". Journal in Ethnopharmacology. 119 (3): 513–537. doi:10.1016/j.jep.2008.08.010. PMID 18775771.

  4. ^Coggon, P.; Farrier, D.S.; Jeffs, P.W.; McPhail, A.T.

    (1970). "Absolute setup for mesembrine along with associated alkaloids: Mesembrine synthesis essay examination with 6-epimesembranol methiodide". J. Chem. Soc.

    How to make sure you Select a fabulous Topic

    B: 1267–1271. doi:10.1039/J29700001267.

  5. ^Loria, Mirielle. J.; Ali, Z; Abe, N; Sufka, k J.; Khan, P v computer essay. A good. (Aug 8, 2014). "Effects of Sceletium tortuosum through rats". J. Ethnopharmacol. 155 (1): customer support words paper. doi:10.1016/j.jep.2014.06.007.

    How for you to Compose a good Activity Essay

    PMID 24930358.

  6. ^Murbach, t S.; Hirka, G; Szakonyiné, We. P.; Gericke, N; Endres, m n (Dec 2014). "A toxicological protection test associated with a consistent plant of Sceletium tortuosum (Zembrin(®)) within rats".

    Food Chem. Toxicol. 74: 190–9. doi:10.1016/j.fct.2014.09.017. PMID 25301237.

  7. ^Bodendorf, K.; Krieger, W., Mesembrine synthesis essay. Pharm. 1957, 290, 441
  8. ^Shamma, M.; Rodriguez, H., Tetrahedron Lett. 1965, 6, 4847. doi:10.1016/S0040-4039(01)89046-8
  9. ^Yamada, S; Otani, He. Tetrahedron Lett. 1971, 12, 1133.

Monoamine reuptake inhibitors

  • Others:Antihistamines (e.g., brompheniramine, chlorphenamine, pheniramine, tripelennamine)
  • Antipsychotics (e.g., loxapine, ziprasidone)
  • Arylcyclohexylamines (e.g., ketamine, phencyclidine)
  • Dopexamine
  • Ephenidine
  • Ginkgo biloba
  • Indeloxazine
  • Nefazodone
  • Opioids (e.g., desmetramadol, methadone, pethidine (meperidine), tapentadol, tramadol, levorphanol)
  • Others:A-80426
  • Amoxapine
  • Antihistamines (e.g., brompheniramine, chlorphenamine, dimenhydrinate, diphenhydramine, mepyramine (pyrilamine), pheniramine, tripelennamine)
  • Antipsychotics (e.g., loxapine, ziprasidone)
  • Arylcyclohexylamines (e.g., 3-MeO-PCP, esketamine, ketamine, methoxetamine, phencyclidine)
  • Cyclobenzaprine
  • Delucemine
  • Dextromethorphan
  • Dextrorphan
  • Efavirenz
  • Medifoxamine
  • Mesembrine
  • Mifepristone
  • MIN-117 (WF-516)
  • N-Me-5-HT
  • Opioids (e.g., dextropropoxyphene, methadone, pethidine (meperidine), levorphanol, tapentadol, tramadol)
  • Roxindole

See also:Receptor/signaling modulators • Monoamine relieving materials • Mesembrine synthesis essay • Dopaminergics • Serotonergics • Monoamine metabolic processes modulators • Monoamine neurotoxins

Shamma’s way designed for complete activity about (±)-mesembrine
Yamada’s asymmetric absolute synthesis regarding (±)-mesembrine

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